Messenger RNA Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Hepatocellular Carcinoma
نویسندگان
چکیده
منابع مشابه
Expression of tissue levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in renal cell carcinoma
BACKGROUND Matrix metalloproteinases (MMPs) are one of the major classes of proteolytic enzymes involved in tumor invasion and metastasis and are inhibited by naturally occurring tissue inhibitors of metalloproteinases (TIMPs). {AU Query: Please verify that corrections made to previous sentence did not alter intended meaning}. In this study, we examined the expression of MMP-2, MMP-9, membrane-...
متن کاملExpression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma
BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and metastasis. Tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 were known to inhibit MMP-9 and MMP-2, respectively. In the present study, w...
متن کاملExpression pattern of metalloproteinases and tissue inhibitors of matrix-metalloproteinases in cycling human endometrium.
The cyclic growth, differentiation, and cell death of endometrium represents the most dynamic example of steroid-driven tissue turnover in human adults. Key effectors in these processes-matrix metalloproteinases (MMPs) and their specific inhibitors (TIMPs)-are regulated by ovarian steroids and, locally, by cytokines. We used reverse transcription-polymerase chain reaction to evaluate the expres...
متن کاملMatrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function.
Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the activities of cells through cell surface receptors...
متن کاملvitrification affects the expression of matrix metalloproteinases and their tissue inhibitors of mouse ovarian tissue
background: one of the most major obstacles of ovarian tissue vitrification is suboptimal developmental competence of follicles. matrix metalloproteinases 2 (mmp-2) and 9 (mmp-9) and their tissue inhibitors timp-1 and timp-2 are involved in the remodeling of the extracellular matrix in the ovaries. objective: this study aimed to evaluate the expression of mmp-2, mmp-9, timp-1, and timp-2 genes ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Clinical Oncology
سال: 1999
ISSN: 0368-2811,1465-3621
DOI: 10.1093/jjco/29.2.58